Dr. Johannes Notni

Enzyme Model Systems:
Sulfur Analogue Carbonic Anhydrase, Latent Matrix Metalloprotease and Thiolate Alkylating Enzymes

• Synthesis of zinc(II) - containing complexes bearing one azamacrocyclic ligand and one thiolate ligand using different thiolates and azamacrocycles



• Investigation of the nucleophilic reactivity of these complexes towards alkyl halides and heterocumulenes (COS, CS₂)

Is there a structure - reactivity correlation?

• DFT optimizations / NBO-analyses of the above described complexes. An existing correlation between certain orbital energies and bond lengths could be a measure for the complexes' nucleophilic reactivity.

• Measurement of reaction kinetics to prove this theory. Is there a possibility to predict the actual reactivities?

Reactions with Heterocumulenes

• Investigation of the mechanism of the reaction of the thiolates with heterocumulenes (associative vs. dissociative reaction paths)

• Heterocumulenes used: CS₂, COS, and CO₂

F-Praktikum Organische Chemie (OC III)

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List of Publications

• Formation of a Unique Zinc Carbamate by CO₂ Fixation: Implications for the Reactivity of Tetra-Azamacrocycle Ligated Zn(II) Complexes. J. Notni, S. Schenk, H. Breitzke, H. Görls, and E. Anders*, Inorg. Chem. 2008, 47, 1382 - 1390.

• [(1-Azulenyl)methanethiolato-κS](1,4,8,12-tetraazacyclopentadecane-κ⁴N)zinc(II) perchlorate. Helmar Görls, Johannes Notni, Ernst Anders*, Acta Cryst. 2008, E64, m205.

• The Missing Link in COS Metabolism: A Model Study on the Reactivation of Carbonic Anhydrase from its Hydrosulfide Analogue. J. Notni, S. Schenk, G. Protoschill-Krebs, J. Kesselmeier, E. Anders*, ChemBioChem 2007, 8, 530.

• Zinc Thiolate Complexes [ZnL_n(SR)]⁺ with Azamacrocyclic Ligands, Part III: The Influence of the Ligand L_n on the Reactivity of the Zinc-bound Thiolate. J. Notni, W. Günther, E. Anders*, Eur. J. Inorg. Chem 2007, 985.

• (p-Methylbenzenethiolato)[tris(3-phenyl-5-methylpyrazolyl)borato]zinc(II). Helmar Görls, Wolfgang Günther, Johannes Notni, Ernst Anders*, Acta Cryst. 2007, E63, m2545.

• (Phenylmethylthiolato)(1,5,9-triazacyclododecane)}zinc(II) thiocyanate. Helmar Görls, Johannes Notni, Ernst Anders*, Acta Cryst. 2007, E63, m2556.

• Diethyl 2,2'-(ethylenediimino)di(cyclopentenecarboxylate). Helmar Görls, Johannes Notni, Kristian Kempe, Ernst Anders*, Acta Cryst. 2007, E63, o4095.

• Carbon Dioxide and related heterocumulenes at zinc and lithium cations: Bioinspired reactions and principles. S. Schenk, J. Notni, U. Köhn, K. Wermann, E. Anders*, Dalton Trans. 2006, 4191-4206.

• Zinc Thiolate Complexes [ZnL_n(SR)]⁺ with Azamacrocyclic Ligands, Part II: The Mechanism of the Reaction with CS₂. J. Notni, S. Schenk, A. Roth, W. Plass, H. Görls, U. Uhlemann, A. Walter, M. Schmitt, J. Popp, S. Chatzipapadopoulos, T. Emmler, H. Breitzke, J. Leppert, G. Buntkowsky, K. Kempe and E. Anders*, Eur. J. Inorg. Chem. 2006, 2783-2791.

• Zinc Thiolate Complexes [ZnL_n(SR)]⁺ with Azamacrocyclic Ligands: Synthesis and Structural Properties. J. Notni, H. Görls, E. Anders*, Eur. J. Inorg. Chem. 2006, 1444-1455.

• Introduction of a high pressure cell for use with Raman microscopy. U. Uhlemann, M. Schmitt, K. L. Oehme, J. Notni, E. Anders, J. Popp*, Journal of Raman Spectroscopy, 2006, 37(1-3), 442-446.

• Acremonol and Acremodiol, New Fungal Bislactones. Albrecht Berg, Johannes Notni, Heinrich Dörfelt, Udo Gräfe*, J. Antibiot. 2002, 55, 660-663.

• The influence of ligand variation on the crystal properties of (η⁴-azadiene)Fe(CO)_3-n(PR₃)_n (n=1,2; R=Cy, Ph, OMe). Daniel Berger, Mandy Erdmann, Johannes Notni and Wolfgang Imhof*, CrystEngComm 2000, 4.